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KMID : 0545120010110010138
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Journal of Microbiology and Biotechnology
2001 Volume.11 No. 1 p.138 ~ p.142
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Anti-Allergic and Anti-Asthmatic Activity of Helioscopinin-A, a Polyphenol Compound, Isolated from Euphorbia helioscopia
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PARK, KWAN HA
KOH, DONGSOO/LEE, SEUNGHO/JUNG,ILLMIN/KIM, KYUNG HYUN/LEE, CHUL-HOON/KIM, KYE-HOON
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Abstract
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During the course of searching for anti-allergic substances from unexplored plant sources, an inhibitor of leukotriene D_4-induced tracheal contraction was isolated from Euphorbia helioscopia. This isolated polyphenol compound, known as helioscopinin-A, showed a certain inhibitory activity on capillary permeability in passive cutaneous anaphylaxis responses of rats and also on antigen-induced bronchial constriction in an experimental. asthma model of guinea pigs. The compound at a high concentration weakly inhibited histamine release from isolated mast cells of rats. It is suggested that this compound is an anti-allergic and anti-asthmatic which exerts its activity through antagonism on leukotriene D_4-induced responses. A partial inhibition of allergic mediator release may also be involved.
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